Controlled growth of nanocomposite thin layer based on Zn-Doped MgO nanoparticles through Sol-Gel technique for biosensor applications

Sana Mansoor; Sammia Shahid; Kinza Ashiq; Norah Alwadai; Mohsin Javed; Shahid Iqbal; Urooj Fatima; Sabah Zaman; Muhammad Nazim Sarwar; Fwzah H. Alshammari; Eslam B. Elkaeed; Nasser S. Awwad; Hala A. Ibrahium

doi:10.1016/j.inoche.2022.109702

Controlled growth of nanocomposite thin layer based on Zn-Doped MgO nanoparticles through Sol-Gel technique for biosensor applications

Sana Mansoor, Sammia Shahid, Kinza Ashiq, Norah Alwadai, Mohsin Javed, Shahid Iqbal, Urooj Fatima, Sabah Zaman, Muhammad Nazim Sarwar, Fwzah H. Alshammari, Eslam B. Elkaeed, Nasser S. Awwad, Hala A. Ibrahium

Research output: Journal Publication › Article › peer-review

19 Citations (Scopus)

Abstract

The sol–gel process was used to manufacture zinc-doped magnesium oxide nano-flakes (Zn-MgO nano-flakes), which were then distributed in chitosan solution to create a nanocomposite thin layer over a glassy carbon electrode (GCE). Chitosan acts as a binder that provides strength and prevents the material on GCE from leaching out. Glucose oxidase (GOx or GOD) an enzyme has been immobilized on the fabricated CH-Zn-MgO nanocomposite thin film by using the physical adsorption method to form a CH-Zn-MgO-GOx nano-sensor. The enzyme GO_x was used to enhance the activity of the nano-sensor by increasing the electron transfer rate. X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis, and UV–vis spectroscopy were employed to characterize the samples in this study. The morphology of Zn-MgO was flakes-like. EDX analysis showed the presence of Zinc (Zn), Magnesium (Mg), and Oxygen (O). Cyclic voltammetry was performed by depositing Zn-MgO on a glassy carbon electrode. Enzymatic nano-sensors showed a peak current of 1.69 × 10^-5 µA and non-enzymatic nano-sensors showed a peak current of 6.16 × 10^-6 µA at 100 µL/mL glucose concentration. The synthesized nano-sensors were then used for the detection of glucose levels.

Original language	English
Article number	109702
Journal	Inorganic Chemistry Communication
Volume	142
DOIs	https://doi.org/10.1016/j.inoche.2022.109702
Publication status	Published - Aug 2022
Externally published	Yes

Keywords

Glucose oxidase
Nanosensors
Sol–gel
Thin film
Zn-MgO

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.inoche.2022.109702

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Mansoor, S., Shahid, S., Ashiq, K., Alwadai, N., Javed, M., Iqbal, S., Fatima, U., Zaman, S., Nazim Sarwar, M., Alshammari, F. H., Elkaeed, E. B., Awwad, N. S., & Ibrahium, H. A. (2022). Controlled growth of nanocomposite thin layer based on Zn-Doped MgO nanoparticles through Sol-Gel technique for biosensor applications. Inorganic Chemistry Communication, 142, Article 109702. https://doi.org/10.1016/j.inoche.2022.109702

@article{a2da1ead09924e3f8b52cee05bdb9e76,

title = "Controlled growth of nanocomposite thin layer based on Zn-Doped MgO nanoparticles through Sol-Gel technique for biosensor applications",

abstract = "The sol–gel process was used to manufacture zinc-doped magnesium oxide nano-flakes (Zn-MgO nano-flakes), which were then distributed in chitosan solution to create a nanocomposite thin layer over a glassy carbon electrode (GCE). Chitosan acts as a binder that provides strength and prevents the material on GCE from leaching out. Glucose oxidase (GOx or GOD) an enzyme has been immobilized on the fabricated CH-Zn-MgO nanocomposite thin film by using the physical adsorption method to form a CH-Zn-MgO-GOx nano-sensor. The enzyme GOx was used to enhance the activity of the nano-sensor by increasing the electron transfer rate. X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis, and UV–vis spectroscopy were employed to characterize the samples in this study. The morphology of Zn-MgO was flakes-like. EDX analysis showed the presence of Zinc (Zn), Magnesium (Mg), and Oxygen (O). Cyclic voltammetry was performed by depositing Zn-MgO on a glassy carbon electrode. Enzymatic nano-sensors showed a peak current of 1.69 × 10-5 µA and non-enzymatic nano-sensors showed a peak current of 6.16 × 10-6 µA at 100 µL/mL glucose concentration. The synthesized nano-sensors were then used for the detection of glucose levels.",

keywords = "Glucose oxidase, Nanosensors, Sol–gel, Thin film, Zn-MgO",

author = "Sana Mansoor and Sammia Shahid and Kinza Ashiq and Norah Alwadai and Mohsin Javed and Shahid Iqbal and Urooj Fatima and Sabah Zaman and {Nazim Sarwar}, Muhammad and Alshammari, {Fwzah H.} and Elkaeed, {Eslam B.} and Awwad, {Nasser S.} and Ibrahium, {Hala A.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = aug,

doi = "10.1016/j.inoche.2022.109702",

language = "English",

volume = "142",

journal = "Inorganic Chemistry Communication",

issn = "1387-7003",

publisher = "Elsevier BV",

}

Mansoor, S, Shahid, S, Ashiq, K, Alwadai, N, Javed, M, Iqbal, S, Fatima, U, Zaman, S, Nazim Sarwar, M, Alshammari, FH, Elkaeed, EB, Awwad, NS & Ibrahium, HA 2022, 'Controlled growth of nanocomposite thin layer based on Zn-Doped MgO nanoparticles through Sol-Gel technique for biosensor applications', Inorganic Chemistry Communication, vol. 142, 109702. https://doi.org/10.1016/j.inoche.2022.109702

TY - JOUR

T1 - Controlled growth of nanocomposite thin layer based on Zn-Doped MgO nanoparticles through Sol-Gel technique for biosensor applications

AU - Mansoor, Sana

AU - Shahid, Sammia

AU - Ashiq, Kinza

AU - Alwadai, Norah

AU - Javed, Mohsin

AU - Iqbal, Shahid

AU - Fatima, Urooj

AU - Zaman, Sabah

AU - Nazim Sarwar, Muhammad

AU - Alshammari, Fwzah H.

AU - Elkaeed, Eslam B.

AU - Awwad, Nasser S.

AU - Ibrahium, Hala A.

PY - 2022/8

Y1 - 2022/8

N2 - The sol–gel process was used to manufacture zinc-doped magnesium oxide nano-flakes (Zn-MgO nano-flakes), which were then distributed in chitosan solution to create a nanocomposite thin layer over a glassy carbon electrode (GCE). Chitosan acts as a binder that provides strength and prevents the material on GCE from leaching out. Glucose oxidase (GOx or GOD) an enzyme has been immobilized on the fabricated CH-Zn-MgO nanocomposite thin film by using the physical adsorption method to form a CH-Zn-MgO-GOx nano-sensor. The enzyme GOx was used to enhance the activity of the nano-sensor by increasing the electron transfer rate. X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis, and UV–vis spectroscopy were employed to characterize the samples in this study. The morphology of Zn-MgO was flakes-like. EDX analysis showed the presence of Zinc (Zn), Magnesium (Mg), and Oxygen (O). Cyclic voltammetry was performed by depositing Zn-MgO on a glassy carbon electrode. Enzymatic nano-sensors showed a peak current of 1.69 × 10-5 µA and non-enzymatic nano-sensors showed a peak current of 6.16 × 10-6 µA at 100 µL/mL glucose concentration. The synthesized nano-sensors were then used for the detection of glucose levels.

AB - The sol–gel process was used to manufacture zinc-doped magnesium oxide nano-flakes (Zn-MgO nano-flakes), which were then distributed in chitosan solution to create a nanocomposite thin layer over a glassy carbon electrode (GCE). Chitosan acts as a binder that provides strength and prevents the material on GCE from leaching out. Glucose oxidase (GOx or GOD) an enzyme has been immobilized on the fabricated CH-Zn-MgO nanocomposite thin film by using the physical adsorption method to form a CH-Zn-MgO-GOx nano-sensor. The enzyme GOx was used to enhance the activity of the nano-sensor by increasing the electron transfer rate. X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis, and UV–vis spectroscopy were employed to characterize the samples in this study. The morphology of Zn-MgO was flakes-like. EDX analysis showed the presence of Zinc (Zn), Magnesium (Mg), and Oxygen (O). Cyclic voltammetry was performed by depositing Zn-MgO on a glassy carbon electrode. Enzymatic nano-sensors showed a peak current of 1.69 × 10-5 µA and non-enzymatic nano-sensors showed a peak current of 6.16 × 10-6 µA at 100 µL/mL glucose concentration. The synthesized nano-sensors were then used for the detection of glucose levels.

KW - Glucose oxidase

KW - Nanosensors

KW - Sol–gel

KW - Thin film

KW - Zn-MgO

UR - http://www.scopus.com/inward/record.url?scp=85133734347&partnerID=8YFLogxK

U2 - 10.1016/j.inoche.2022.109702

DO - 10.1016/j.inoche.2022.109702

M3 - Article

AN - SCOPUS:85133734347

SN - 1387-7003

VL - 142

JO - Inorganic Chemistry Communication

JF - Inorganic Chemistry Communication

M1 - 109702

ER -

Controlled growth of nanocomposite thin layer based on Zn-Doped MgO nanoparticles through Sol-Gel technique for biosensor applications

Abstract

Keywords

ASJC Scopus subject areas

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