Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy

Peng Wang; Qiang Wu; Fuyan Wang; Yaping Zhang; Liying Tong; Tao Jiang; Chenjie Gu; Shuiping Huang; Hongxi Wang; Shizhong Bu; Jun Zhou

doi:10.2217/nnm-2018-0126

Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy

Peng Wang, Qiang Wu, Fuyan Wang, Yaping Zhang, Liying Tong, Tao Jiang, Chenjie Gu, Shuiping Huang, Hongxi Wang, Shizhong Bu, Jun Zhou

Department of Electrical and Electronic Engineering

Research output: Journal Publication › Article › peer-review

15 Citations (Scopus)

Abstract

A novel method is proposed for quantifying the Raman intensity as a function of gold mass in a single cell based on the Raman mapping and inductively coupled plasma-mass spectrometry techniques. A high-efficiency plasmonic photothermal therapy has also been achieved by adjusting the laser wavelength, laser power and exposure time, resulting in most of the HL-7702 cells surviving, whereas most of the HepG2 cells get damaged.

Original language	English
Pages (from-to)	2245-2259
Number of pages	15
Journal	Nanomedicine
Volume	13
Issue number	18
DOIs	https://doi.org/10.2217/nnm-2018-0126
Publication status	Published - 1 Sept 2018

Keywords

ICP-MS
Raman mapping
cellular uptake
cytotoxicity
gold nanoparticles
human hepatic immortalized cell lines (HL-7702)
human hepatocellular carcinoma cell lines (HepG2)
plasmonic photothermal therapy
surface enhanced Raman scattering (SERS)

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm-2018-0126

Cite this

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title = "Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy",

abstract = "A novel method is proposed for quantifying the Raman intensity as a function of gold mass in a single cell based on the Raman mapping and inductively coupled plasma-mass spectrometry techniques. A high-efficiency plasmonic photothermal therapy has also been achieved by adjusting the laser wavelength, laser power and exposure time, resulting in most of the HL-7702 cells surviving, whereas most of the HepG2 cells get damaged.",

keywords = "ICP-MS, Raman mapping, cellular uptake, cytotoxicity, gold nanoparticles, human hepatic immortalized cell lines (HL-7702), human hepatocellular carcinoma cell lines (HepG2), plasmonic photothermal therapy, surface enhanced Raman scattering (SERS)",

author = "Peng Wang and Qiang Wu and Fuyan Wang and Yaping Zhang and Liying Tong and Tao Jiang and Chenjie Gu and Shuiping Huang and Hongxi Wang and Shizhong Bu and Jun Zhou",

note = "Publisher Copyright: {\textcopyright} 2018 2018 Jun Zhou, Ningbo University.",

year = "2018",

month = sep,

day = "1",

doi = "10.2217/nnm-2018-0126",

language = "English",

volume = "13",

pages = "2245--2259",

journal = "Nanomedicine",

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TY - JOUR

T1 - Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy

AU - Wang, Peng

AU - Wu, Qiang

AU - Wang, Fuyan

AU - Zhang, Yaping

AU - Tong, Liying

AU - Jiang, Tao

AU - Gu, Chenjie

AU - Huang, Shuiping

AU - Wang, Hongxi

AU - Bu, Shizhong

AU - Zhou, Jun

PY - 2018/9/1

Y1 - 2018/9/1

N2 - A novel method is proposed for quantifying the Raman intensity as a function of gold mass in a single cell based on the Raman mapping and inductively coupled plasma-mass spectrometry techniques. A high-efficiency plasmonic photothermal therapy has also been achieved by adjusting the laser wavelength, laser power and exposure time, resulting in most of the HL-7702 cells surviving, whereas most of the HepG2 cells get damaged.

AB - A novel method is proposed for quantifying the Raman intensity as a function of gold mass in a single cell based on the Raman mapping and inductively coupled plasma-mass spectrometry techniques. A high-efficiency plasmonic photothermal therapy has also been achieved by adjusting the laser wavelength, laser power and exposure time, resulting in most of the HL-7702 cells surviving, whereas most of the HepG2 cells get damaged.

KW - ICP-MS

KW - Raman mapping

KW - cellular uptake

KW - cytotoxicity

KW - gold nanoparticles

KW - human hepatic immortalized cell lines (HL-7702)

KW - human hepatocellular carcinoma cell lines (HepG2)

KW - plasmonic photothermal therapy

KW - surface enhanced Raman scattering (SERS)

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DO - 10.2217/nnm-2018-0126

M3 - Article

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AN - SCOPUS:85054890199

SN - 1743-5889

VL - 13

SP - 2245

EP - 2259

JO - Nanomedicine

JF - Nanomedicine

IS - 18

ER -

Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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