Identification and characterization of solid-state nature of 2-chloromandelic acid

Quan He; Jesse Zhu; Hassan Gomaa; Michael Jennings; Sohrab Rohani

doi:10.1002/jps.21560

Identification and characterization of solid-state nature of 2-chloromandelic acid

Quan He, Jesse Zhu, Hassan Gomaa, Michael Jennings, Sohrab Rohani

Research output: Journal Publication › Article › peer-review

20 Citations (Scopus)

Abstract

The racemate and enantiomers of 2-chloromandelic acid were characterized by SS-NMR, XRPD, and FTIR. The binary melting point phase diagram was constructed by DSC (differential scanning calorimetry). The solid-state nature of 2-chloromandelic acid was identified to be a racemic compound. The crystal structure of racemic compound was determined to be monoclinic P2₁/c.

Original language	English
Pages (from-to)	1835-1844
Number of pages	10
Journal	Journal of Pharmaceutical Sciences
Volume	98
Issue number	5
DOIs	https://doi.org/10.1002/jps.21560
Publication status	Published - May 2009
Externally published	Yes

Keywords

2-chloromandelic acid
Conglomerate
Crystal structure
Differential scanning calorimetry
Enantiomer
Melting point diagram
Racemate

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.21560

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abstract = "The racemate and enantiomers of 2-chloromandelic acid were characterized by SS-NMR, XRPD, and FTIR. The binary melting point phase diagram was constructed by DSC (differential scanning calorimetry). The solid-state nature of 2-chloromandelic acid was identified to be a racemic compound. The crystal structure of racemic compound was determined to be monoclinic P21/c.",

keywords = "2-chloromandelic acid, Conglomerate, Crystal structure, Differential scanning calorimetry, Enantiomer, Melting point diagram, Racemate",

author = "Quan He and Jesse Zhu and Hassan Gomaa and Michael Jennings and Sohrab Rohani",

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AU - Zhu, Jesse

AU - Gomaa, Hassan

AU - Jennings, Michael

AU - Rohani, Sohrab

PY - 2009/5

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AB - The racemate and enantiomers of 2-chloromandelic acid were characterized by SS-NMR, XRPD, and FTIR. The binary melting point phase diagram was constructed by DSC (differential scanning calorimetry). The solid-state nature of 2-chloromandelic acid was identified to be a racemic compound. The crystal structure of racemic compound was determined to be monoclinic P21/c.

KW - 2-chloromandelic acid

KW - Conglomerate

KW - Crystal structure

KW - Differential scanning calorimetry

KW - Enantiomer

KW - Melting point diagram

KW - Racemate

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ER -

Identification and characterization of solid-state nature of 2-chloromandelic acid

Abstract

Keywords

ASJC Scopus subject areas

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