TY - JOUR
T1 - Recent advances and perspectives of aggregation-induced emission as an emerging platform for detection and bioimaging
AU - Khan, Imran Mahmood
AU - Niazi, Sobia
AU - Iqbal Khan, Muhammad Kashif
AU - Pasha, Imran
AU - Mohsin, Ali
AU - Haider, Junaid
AU - Iqbal, Muhammad Waheed
AU - Rehman, Abdur
AU - Yue, Lin
AU - Wang, Zhouping
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/10
Y1 - 2019/10
N2 - The emergent arena of bio-nanotechnology aims at modernizing the detection and bioimaging discipline via the introduction of aggregation-induced emission (AIE)-based tools. AIE is a unique photophysical phenomenon because of the photoemission of the propeller-like molecules that could be significantly enhanced after aggregation. AIE differs immensely from the generally recognized aggregation-caused emission quenching (ACQ) observed in numerous conventional luminophores that own well-conjugated and planar structures. The luminogens with AIE aspects (AIEgens) are more promising to be applied in various research front. Driven by ever-increasing interests for good applicability, fast response, excellent fluorescence and sensitivity, the fluorescent AIE-probes with numerous working methodology and innovative functionalities are prospering at an astonishing speed. In this review, we have presented a brief introduction of AIE with development history, comparison with conventional fluorophores, expected working methodology, discuss the structure-property relationship of the AIEgens and summarized the recent progress of AIE molecular and nanomaterial probe over the past 3 years with their respective mechanism of detection and bioimaging. In addition, this work provides a novel platform for the preparation and potential applications of multifunctional AIE-active nano-systems responsiveness for various detection of analytes and cell bioimaging with respective examples and also encompasses the recent progress, challenges and potential breakthroughs.
AB - The emergent arena of bio-nanotechnology aims at modernizing the detection and bioimaging discipline via the introduction of aggregation-induced emission (AIE)-based tools. AIE is a unique photophysical phenomenon because of the photoemission of the propeller-like molecules that could be significantly enhanced after aggregation. AIE differs immensely from the generally recognized aggregation-caused emission quenching (ACQ) observed in numerous conventional luminophores that own well-conjugated and planar structures. The luminogens with AIE aspects (AIEgens) are more promising to be applied in various research front. Driven by ever-increasing interests for good applicability, fast response, excellent fluorescence and sensitivity, the fluorescent AIE-probes with numerous working methodology and innovative functionalities are prospering at an astonishing speed. In this review, we have presented a brief introduction of AIE with development history, comparison with conventional fluorophores, expected working methodology, discuss the structure-property relationship of the AIEgens and summarized the recent progress of AIE molecular and nanomaterial probe over the past 3 years with their respective mechanism of detection and bioimaging. In addition, this work provides a novel platform for the preparation and potential applications of multifunctional AIE-active nano-systems responsiveness for various detection of analytes and cell bioimaging with respective examples and also encompasses the recent progress, challenges and potential breakthroughs.
KW - AIE
KW - Bioimaging
KW - Challenges
KW - Detection
KW - Fluorescence
KW - Nanomaterial
KW - Sensors
UR - http://www.scopus.com/inward/record.url?scp=85071834839&partnerID=8YFLogxK
U2 - 10.1016/j.trac.2019.115637
DO - 10.1016/j.trac.2019.115637
M3 - Review article
AN - SCOPUS:85071834839
SN - 0165-9936
VL - 119
JO - TrAC - Trends in Analytical Chemistry
JF - TrAC - Trends in Analytical Chemistry
M1 - 115637
ER -