TY - JOUR
T1 - Research update of emergent gold nanoclusters
T2 - A reinforced approach towards evolution, synthesis mechanism and application
AU - Khan, Imran Mahmood
AU - Niazi, Sobia
AU - Yue, Lin
AU - Zhang, Yin
AU - Pasha, Imran
AU - Iqbal Khan, Muhammad Kashif
AU - Akhtar, Wasim
AU - Mohsin, Ali
AU - Chughati, Muhammad Farhan Jahangir
AU - Wang, Zhouping
N1 - Publisher Copyright:
© 2022
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Fluorescent biosensors and imaging devices have gained fervent consideration due to their prime functionality in biological. Among fluorescent nanomaterial (FNMs), the ultra-small gold nanoclusters (AuNCs) have gained promising attention with respect to extra-ordinary properties of bright fluorescence, economical synthesis, higher photostability, and biocompatibility, and deep tissue penetration. Therefore, the prior decades comprehended the revolutions in the field of real-time monitoring devices, nanotechnology-based biosensing, and bioimaging sensors. The present review primarily focuses on metal NCs (MNCs) and their advantages, a brief introduction of AuNCs along with history prospective and development, fundamental aspects regarding AuNCs quality and fluorescence, limitations and advantages of AuNCs, sensing mechanism, expected synthesis principle, and summarized the recent progress of AuNCs probe over the last 3 years (2019–2021) with their respective detection and bioimaging mechanism and synthesis principle. Moreover, the present work also serves as a novel stratagem for the preparation and potential applications of multifunctional AuNCs nano-systems responsiveness for various analytes detection and cell bioimaging with respective examples. At last, we described the challenges associated with the application of AuNCs based on recent signs of progress.
AB - Fluorescent biosensors and imaging devices have gained fervent consideration due to their prime functionality in biological. Among fluorescent nanomaterial (FNMs), the ultra-small gold nanoclusters (AuNCs) have gained promising attention with respect to extra-ordinary properties of bright fluorescence, economical synthesis, higher photostability, and biocompatibility, and deep tissue penetration. Therefore, the prior decades comprehended the revolutions in the field of real-time monitoring devices, nanotechnology-based biosensing, and bioimaging sensors. The present review primarily focuses on metal NCs (MNCs) and their advantages, a brief introduction of AuNCs along with history prospective and development, fundamental aspects regarding AuNCs quality and fluorescence, limitations and advantages of AuNCs, sensing mechanism, expected synthesis principle, and summarized the recent progress of AuNCs probe over the last 3 years (2019–2021) with their respective detection and bioimaging mechanism and synthesis principle. Moreover, the present work also serves as a novel stratagem for the preparation and potential applications of multifunctional AuNCs nano-systems responsiveness for various analytes detection and cell bioimaging with respective examples. At last, we described the challenges associated with the application of AuNCs based on recent signs of progress.
KW - AuNCs sensor
KW - Detection. bioimaging
KW - Fluorescence
KW - History
UR - http://www.scopus.com/inward/record.url?scp=85123930981&partnerID=8YFLogxK
U2 - 10.1016/j.talanta.2022.123228
DO - 10.1016/j.talanta.2022.123228
M3 - Review article
C2 - 35131564
AN - SCOPUS:85123930981
SN - 0039-9140
VL - 241
JO - Talanta
JF - Talanta
M1 - 123228
ER -