@inproceedings{e826a2b9ce644d8c9d58273885401a25,
title = "TANTIGEN 2.0: An online database and analysis platform for tumor T cell antigens",
abstract = "We previously developed TANTIGEN, a comprehensive web-based database cataloging more than 1,000 T cell epitopes and HLA ligands from 292 tumor antigens. TANTIGEN 2.0 is significantly expanded the number and coverage of immune response targets (T cell epitopes and HLA ligands) of previously cataloged tumor antigens. We expanded the number of cataloged tumor antigens to more than 4,000 and have added their reported targets of immune responses. We also included neoantigens, a new class of tumor antigens generated through mutations that results in a new amino acid sequence in tumor antigens. TANTIGEN 2.0 contains validated TCR sequences specific for cognate T cell epitopes. Gene expression information was extracted from tumor antigen gene/mRNA/protein expression information in major human cancers provided by Human Pathology Atlas. TANTIGEN 2.0 provides a rich data resource for tumor-associated epitope and neoepitope discovery studies. It is freely available at http://projects.met-hilab.org/tadb.",
keywords = "T cell epitope prediction, cancer vaccine, immunotherapy, neoantigen, neoepitope, tumor antigen",
author = "Guanglan Zhang and Lou Chitkushev and Keskin, {Derin B.} and Vladimir Brusic",
note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019 ; Conference date: 18-11-2019 Through 21-11-2019",
year = "2019",
month = nov,
doi = "10.1109/BIBM47256.2019.8983392",
language = "English",
series = "Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "2228--2231",
editor = "Illhoi Yoo and Jinbo Bi and Hu, {Xiaohua Tony}",
booktitle = "Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019",
address = "United States",
}
