TY - JOUR
T1 - Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013
AU - Kim, Bongyoung
AU - Hwang, Hyeonjun
AU - Kim, Jieun
AU - Lee, Myoung Jae
AU - Pai, Hyunjoo
N1 - Publisher Copyright:
© 2020 The Korean Association of Internal Medicine.
PY - 2020/5
Y1 - 2020/5
N2 - Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to def ined daily dose (DDD)/1,000 patient-days. We def ined 3rd generation cephalosporins, 4th generation cephalosporins, β-lactam/β-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazo-lidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens. Other antibiotic classes were defined as nonbroad-spectrum antibiotics. Results: Mean antibiotic consumption was 920.69 DDD/1,000 patient-days. The proportions of broad-spectrum antibiotics, antibiotics against MDR pathogens, and nonbroad-spectrum antibiotics were 41.8% (384.48/920.69), 3.5% (32.24/920.69), and 54.7% (503.97/920.69), respectively. Consumption of broad-spectrum antibiotics (coefficient for time 0.141; p = 0.049) and antibiotics against MDR pathogens (coefficient for time 0.185; p < 0.001) showed a significant increasing trend over the study period. Nonbroad-spectrum antibiotic consumption showed a signif icant decreasing trend over the study period (coefficient for time –2.601; p < 0.001). Conclusions: Over the 10-year period, a stepwise increase in the consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens was observed at a tertiary care hospital in Korea. Conversely, during the same period, non-broad-spectrum antibiotic consumption showed a significant decreasing trend.
AB - Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to def ined daily dose (DDD)/1,000 patient-days. We def ined 3rd generation cephalosporins, 4th generation cephalosporins, β-lactam/β-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazo-lidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens. Other antibiotic classes were defined as nonbroad-spectrum antibiotics. Results: Mean antibiotic consumption was 920.69 DDD/1,000 patient-days. The proportions of broad-spectrum antibiotics, antibiotics against MDR pathogens, and nonbroad-spectrum antibiotics were 41.8% (384.48/920.69), 3.5% (32.24/920.69), and 54.7% (503.97/920.69), respectively. Consumption of broad-spectrum antibiotics (coefficient for time 0.141; p = 0.049) and antibiotics against MDR pathogens (coefficient for time 0.185; p < 0.001) showed a significant increasing trend over the study period. Nonbroad-spectrum antibiotic consumption showed a signif icant decreasing trend over the study period (coefficient for time –2.601; p < 0.001). Conclusions: Over the 10-year period, a stepwise increase in the consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens was observed at a tertiary care hospital in Korea. Conversely, during the same period, non-broad-spectrum antibiotic consumption showed a significant decreasing trend.
KW - Anti-bacterial agents
KW - Hospitals
KW - Korea
UR - http://www.scopus.com/inward/record.url?scp=85084528116&partnerID=8YFLogxK
U2 - 10.3904/kjim.2017.332
DO - 10.3904/kjim.2017.332
M3 - Article
C2 - 30257553
AN - SCOPUS:85084528116
SN - 1226-3303
VL - 35
SP - 703
EP - 713
JO - Korean Journal of Internal Medicine
JF - Korean Journal of Internal Medicine
IS - 3
ER -