Total synthesis study of rauvomines A and B: Construction of the pentacyclic core structure

Binglu Wu, Zhi Jiang Jiang, Jianbo Tang, Zhanghua Gao, Hongze Liang, Bencan Tang, Jia Chen, Kewei Lei

Research output: Journal PublicationArticlepeer-review

6 Citations (Scopus)

Abstract

A synthetic route has been developed for the core scaffold of rauvomines, which possess an abnormal sarpagine-type backbone without the C20-methylene substitution. The E-ring annulation was achieved by a TiCl4-catalyzed Mukaiyama-Aldol reaction with a moderate yield of 70%.

Original languageEnglish
Pages (from-to)1685-1689
Number of pages5
JournalOrganic Chemistry Frontiers
Volume7
Issue number13
DOIs
Publication statusPublished - 7 Jul 2020

ASJC Scopus subject areas

  • Organic Chemistry

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