Variants in the nestin gene and coronary heart disease

Weihua Meng; Chris C. Patterson; Christine Belton; Anne Hughes; Pascal P. McKeown

doi:10.1253/circj.CJ-08-0262

Variants in the nestin gene and coronary heart disease

Weihua Meng, Chris C. Patterson, Christine Belton, Anne Hughes, Pascal P. McKeown

Research output: Journal Publication › Article › peer-review

5 Citations (Scopus)

Abstract

Background: The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and Results: The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion: Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.

Original language	English
Pages (from-to)	1538-1539
Number of pages	2
Journal	Circulation Journal
Volume	72
Issue number	9
DOIs	https://doi.org/10.1253/circj.CJ-08-0262
Publication status	Published - 2008
Externally published	Yes

Keywords

Coronary heart disease
Nestin
Polymorphism

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1253/circj.CJ-08-0262

Cite this

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title = "Variants in the nestin gene and coronary heart disease",

abstract = "Background: The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and Results: The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion: Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.",

keywords = "Coronary heart disease, Nestin, Polymorphism",

author = "Weihua Meng and Patterson, {Chris C.} and Christine Belton and Anne Hughes and McKeown, {Pascal P.}",

year = "2008",

doi = "10.1253/circj.CJ-08-0262",

language = "English",

volume = "72",

pages = "1538--1539",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "9",

}

TY - JOUR

T1 - Variants in the nestin gene and coronary heart disease

AU - Meng, Weihua

AU - Patterson, Chris C.

AU - Belton, Christine

AU - Hughes, Anne

AU - McKeown, Pascal P.

PY - 2008

Y1 - 2008

N2 - Background: The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and Results: The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion: Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.

AB - Background: The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and Results: The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion: Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.

KW - Coronary heart disease

KW - Nestin

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=50449099919&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-08-0262

DO - 10.1253/circj.CJ-08-0262

M3 - Article

C2 - 18724036

AN - SCOPUS:50449099919

SN - 1346-9843

VL - 72

SP - 1538

EP - 1539

JO - Circulation Journal

JF - Circulation Journal

IS - 9

ER -

Variants in the nestin gene and coronary heart disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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