Abstract
When a population is in equilibrium, both genotype and allele frequencies remain constant from one generation to the next. If a population satisfies the conditions necessary to ensure that genotypes are in Hardy-Weinberg proportions, it follows that it is also in equilibrium. Even if a population does not satisfy the Hardy-Weinberg conditions, however, it may still be in equilibrium. The frequency of recessive alleles preventing individual monkey flower plants from producing pollen, for example, is likely to represent a balance between the tendency of natural selection to eliminate the recessive allele and recurrent mutation that tends to increase its frequency. A population in which such forces are balanced might be said to be in dynamic equilibrium. Two dynamic equilibrium points in a gene regulatory network correspond to biological switch to a gene circuit.
Original language | English |
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Title of host publication | Brenner's Encyclopedia of Genetics |
Subtitle of host publication | Second Edition |
Publisher | Elsevier Inc. |
Pages | 514-516 |
Number of pages | 3 |
ISBN (Electronic) | 9780080961569 |
ISBN (Print) | 9780123749840 |
DOIs | |
Publication status | Published - 27 Feb 2013 |
Externally published | Yes |
Keywords
- Akt proteins
- Biological switch
- Bistability
- Differential equations
- Dynamic equilibrium
- Gene regulatory circuits
- Genotype and allele frequencies
- Hardy-Weinberg proportions and conditions
- Mathematical models
- Monkey flower plants
- P53 protein
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry,Genetics and Molecular Biology
- General Medicine